Intermediate of Entecavir 4 - Names and Identifiers
Name | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
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Synonyms | Dibenzyl Entecavir Entecavir Impurity 4 Entecavir intermediate 8 Entecavir intermediate N8 Entecavir InterMediate N-1 Intermediate of Entecavir 4 Entecavir intermediate N-1
Entecavir InterMediate VIII IsoMer The intermediate of Entecavir hydrate 10-Oxy Iminostilbene Carbonyl Chloride Dibenzyl Entecavir (3',5'-Di-O-Benzyl Entecavir) 2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-9H-purin-6-ol (1S,3R,4S)-2-amino-9-[4-(benzyloxy)-3-(benzyloxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one (1S,3R,4S)-2-amino-9-[4-(benzyloxy)-3-(benzyloxymethyl)- 2-methylidene-cyclopentyl]-6H-purin-6-one 2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one 2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclophentyl)-1H-purin-6(9H)-one 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one 2-aMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(benzyloxy)-3-[(benzyloxy)Methyl]cyclopentyl]-6H-Purin-6-one [1S-(1α,3α,4β)]-2-AMino-1,9-dihydro-9-[2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H 2-amino-9-{(1S,3R,4S)-4-(benzyloxy)-3-[(benzyloxy)methyl]-2-methylidenecyclopentyl}-1,9-dihydro-6H-purin-6-one 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one(E8) 2-AMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H-purin-6-one 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-
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CAS | 142217-81-0
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EINECS | 1312995-182-4 |
InChI | InChI=1/C26H27N5O3/c1-17-20(15-33-13-18-8-4-2-5-9-18)22(34-14-19-10-6-3-7-11-19)12-21(17)31-16-28-23-24(31)29-26(27)30-25(23)32/h2-11,16,20-22H,1,12-15H2,(H3,27,29,30,32)/t20-,21-,22-/m0/s1 |
Intermediate of Entecavir 4 - Physico-chemical Properties
Molecular Formula | C26H27N5O3
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Molar Mass | 457.52 |
Density | 1.34 |
Melting Point | 245-247°C (dec.) |
Solubility | DMSO (Slightly) |
Appearance | Solid |
Color | White to Pale Beige |
pKa | 9?+-.0.20(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.679 |
Intermediate of Entecavir 4 - Risk and Safety
Intermediate of Entecavir 4 - Introduction
2-Amino -1, 9-dihydro-9-[(1S,3R,4S)-4-benzyloxy-3-benzyloxymethyl-2-methylenecyclopentyl]-6H-purin-6-one is an organic compound with the formula C23H26N6O3.
Properties of this compound:
1. Appearance: A solid, usually white crystalline.
2. solubility: can be dissolved in some organic solvents, such as dichloromethane, ethyl acetate and methanol, but the solubility in water is low.
Use of this compound:
2-Amino -1, 9-dihydro-9-[(1S,3R,4S)-4-benzyloxy-3-benzyloxymethyl-2-methylenecyclopentyl]-6H-purin-6-One is a chemical reagent, often used in laboratory research, especially during drug synthesis.
Preparation of this compound:
2-amino -1, 9-dihydro-9-[(1S,3R,4S)-4-benzyloxy-3-benzyloxymethyl-2-methylenecyclopentyl]-6H-purin-6-one There are many ways to prepare it, which can be synthesized through different reaction steps and intermediates. The specific preparation method will involve complex organic synthesis technology, and generally requires corresponding experimental conditions and equipment.
Safety information for this compound:
1. 2-amino -1,9-dihydro -9-[(1S,3R,4S)-4-benzyloxy -3-benzyloxy methyl -2-methylene cyclopentyl]-6H-purine -6-one is a chemical reagent with potential chemical risks. please pay attention to the correct operation method and abide by laboratory safety regulations.
2. avoid contact with eyes, skin and mucous membranes, and avoid inhaling its powder or gas.
3. in the use of the process should wear personal protective equipment, such as gloves, goggles and protective clothing.
4. storage should be sealed, away from open flame and heat source, avoid contact with oxidant, strong acid or strong alkali and other substances.
5. In case of accidental contact or inhalation, please seek medical help immediately and provide the corresponding safety data sheet.
Last Update:2024-04-09 15:17:52